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Systemic Medications and Endodontic Outcomes – Ep. 62

Guest: Ashraf F. Fouad, D.D.S., M.S.

The episode of Endo Voices highlights the brilliant mind of endodontic legend Dr. Ashraf Fouad, who delves deep into the intricacies of medications and their effects on healing, particularly in the context of endodontics. Dr. Fouad explains the challenges in establishing causation versus association in medical studies, emphasizing the importance of rigorous observational studies for generating data. He explores various medications’ impacts on healing, from diabetes treatments like Metformin to biologicals and monoclonal antibodies used in autoimmune diseases and cancer treatment. Dr. Fouad covers biochemical mechanisms of action detailing how medications influence healing processes, all the while drawing from extensive research and clinical observations. His insights extend to the complexities of systemic conditions like diabetes and their interplay with oral health, underscoring the need for interdisciplinary collaboration between dentistry and medicine. He emphasizes the significance of longitudinal studies and careful patient assessment, especially for those at risk due to systemic conditions or medication regimens.

Episodes of Endo Voices may include opinion, speculation and other statements not verifiable in the scientific method and do not necessarily reflect the views of AAE or the sponsor(s). Listeners should use their best judgment in evaluating the merits of any content.

Episode Resources

  1. Fouad, A., Barry, J., Russo, J., Radolf, J., & Zhu, Q. (2002). Periapical lesion progression with controlled microbial inoculation in a type I diabetic mouse model. Journal of endodontics28(1), 8-16.
  2. Alghofaily, Maha et al. Association of Chronic Systemic Medications with the Incidence, Prevalence, or Healing of Endodontic Disease: A Systematic Review Journal of Endodontics, Volume 48, Issue 12, 1458 - 1467
  3. Aminoshariae, Anita et al. Association between Systemic Diseases and Endodontic Outcome: A Systematic Review Journal of Endodontics, Volume 43, Issue 4, 514 - 519
  4. Segura‐Egea, J. J., Cabanillas‐Balsera, D., Martín‐González, J., & Cintra, L. T. (2023). Impact of systemic health on treatment outcomes in endodontics. International Endodontic Journal56, 219-235.